Publications
2026
2025
  • Joo, J. H., Lee, S., & Kim, K. P. (2025). Precision gene editing: The power of CRISPR-Cas in modern genetics. Molecular Therapy Nucleic Acids.
  • Yoon, S., Lee, S., Kwon, H., Kim, H. S., Joo, J. H., Hong, S., … & Chae, J. H. (2025). Biallelic BRF2 mutations disrupt redox homeostasis as etiological factors in syndromic immunodeficiency and developmental disorders. Molecular Therapy.
  • Leon, V. A., Markowitz, T. E., Hong, S., Raghavan, A. R., Heldrich, J., Kim, K. P., & Hochwagen, A. (2025). Crossover designation recruits condensin to reorganize the meiotic chromosome axis. Current Biology.
  • Choi, H., Lee, J. S., Joo, J. H., Lee, S., & Kim, K. P. (2025). Recombination-coupled DNA synthesis facilitates post-invasion steps in meiotic crossover and noncrossover formations. Nucleic Acids Research.
  • Choi, E. H., & Kim, K. P. (2025). Cohesin and condensin regulate chromosome topology and play an essential role in maintaining pluripotency in embryonic stem cells. Scientific reports.
2024
  • Huang, P.C., Hong, S., Alnaser, H.F., Mimitou, E.P., Kim, K.P., Murakami, H., and Keeney, S. (2024). Meiotic DNA break resection and recombination rely on chromatin remodeler Fun30. The EMBO journal.
  • Kim, SH., Yoon, S., Kim KP. (2024). Boosting CRISPR-Cas9 efficiency through enhanced homologous recombination. Molecular Therapy Nucleic Acids.
  • Jin, H., Yeom, JH., Shin, E., Ha, Y., Liu, H., Kim, D., Joo, M., Kim YH, Kim HK, Ryu, M., Kim HM, Kim J., Kim KP, Hahn, Y., Bae, J., and Lee, K. (2024). 5′-tRNAGly(GCC) halves generated by IRE1α are linked to the ER stress response. Nature communications.
  • Jeong H. Joo, Soogil Hong, Mika T. Higashide, Eui-Hwan Choi, Seobin Yoon, Min-Su Lee, Hyun Ah Kang, Akira Shinohara, Nancy Kleckner and Keun P. Kim (2024). RPA Interacts with Rad52 to Promote Meiotic Crossover and Noncrossover Recombination. Nucleic Acids Research.
2023
  • Seo Jung Park, Seobin Yoon, Eui-Hwan Choi, Hana Hyeon, Kangseok Lee, and Keun Pil Kim (2023). Elevated expression of exogenous RAD51 enhances the CRISPR/Cas9-mediated genome editing efficiency. BMB Reports, BMB-22-149.
  • Seobin Yoon, Eui-Hwan Choi, Seo Jung Park, and Keun Pil Kim (2023). α-Kleisin subunit of cohesin preserves the genome integrity of embryonic stem cells. BMB Reports, BMB-22-106.
  • Seobin Yoon, Bum-Kyu Lee and Keun Pil Kim (2023). Caffeine enhances chemosensitivity to irinotecan in the treatment of colorectal cancer. Phytomedicine, 121, 155120.
  • Kiwon Rhee, Hyungseok Choi, Keun P. Kim and Jeong H. Joo (2023). A Method for Physical Analysis of Recombination Intermediates in Saccharomyces cerevisiae. Journal of Microbiology, 61(11): 939-951.
2022
  • Young Eun Koh, Eui-Hwan Choi, Jung-Woong Kim, and Keun Pil Kim (2022). The Kleisin subunits of cohesin are involved in the fate determination of embryonic stem cells. Mol cells, 45(11): 820-832.
  • Min-Kyung Jo, Kiwon Rhee, Keun Pil Kim, and Soogil Hong (2022). Yeast polyubiquitin unit regulates synaptonemal complex formation and recombination during meiosis. Journal of Microbiology, 60(7): 705-714.
  • Jeong Hwan Joo, Hyun Ah Kang, Keun Pil Kim, and Soogil Hong (2022). Meiotic prophase roles of Pds5 in recombination and chromosome condensation in budding yeast. Journal of Microbiology, 60(2): 177-186.
  • Eui‑Hwan Choi, Seobin Yoon, Young Eun Koh, Tae Kyung Hong, Jeong Tae Do, Bum‑Kyu Lee,Yoonsoo Hahn and Keun P. Kim (2022). Meiosis-specific cohesin complexes display essential and distinct roles in mitotic embryonic stem cell chromosomes. Genome biology, 23:70.
2021
  • Min-Su Lee, Mika T Higashide, Hyungseok Choi, Ke Li, Soogil Hong, Kangseok Lee, Akira Shinohara, Miki Shinoara, Keun P Kim. (2021). The synaptonemal complex central region modulates crossover pathways and feedback control of meiotic double-strand break formation. Nucleic Acids Research.
2020
  • Min-Su Lee, Jung Whan Joo, Hyungseok Choi, Hyun Ah Kang, and Keunpil Kim. (2020). Mec1 Modulates Interhomolog Crossover and Interplays with Tel1 at Post Double-Strand Break Stages. Journal of Microbiology and Biotechnology. 30(0), 1–7
  • Hanyong Jin, Boeun Lee, Yongyang Luo, Yuri Choi, Eui-Hwan Choi, Hong Jin, Kee-Beom Kim,Sang Beom Seo, Yong-Hak Kim, Hyung Ho Lee✉, Keun Pil Kim✉, Kangseok Lee✉&Jeehyeon Bae✉. (2020). FOXL2 Directs DNA Double-strand Break Repair Pathways by Differentially Interacting with Ku. Nature Communication. 11:2010
  • Eui-Hwan Choi, Seobin Yoon, Young Eun Koh, Young Jin Seo and Keum Pil Kim.(2020). Maintenance of genome Intergrity and Actove Homologous Recombination in Embryonic Stem Cells. Experimental & Molecular Medicine.
2019
  • Hong SG, Joo JH, Yun HS, Kim KP. (2019). The nature of meiotic chromosome dynamics and recombination in budding yeast. Journal of Microbiology. 57.
  • Yun HS, Kim KP. (2019).Ku complex suppresses recombination in the absence of MRX activity during budding yeast meiosis. BMB reports. 52(10).
  • Choi EH, Kim KP. (2019). E2F1 facilitates DNA break repair by localizing to break sites and enhancing the expression of homologous recombination factors. Experimental & Molecular Medicine. 51, 106.
  • Hong SG, Joo JH, Yun HS, Kleckner N, Kim KP. (2019). Recruitment of Rec8, Pds5 and Rad61/Wapl to meiotic homolog pairing, recombination, axis formation and S-phase. Nucleic Acids Research. 22, 11691–11708.
2018
  • Yoon S, Choi EH, Kim JW, Kim KP. (2018). Structured Illumination Microscopy Imaging Reveals Synaptonemal Complex and Localization of Replication Protein A during Mammalian Meiosis. Experimental & Molecular Medicine. 50, 112.
  • Kim KP, Mirkin EV. (2018). So similar yet so different: The two ends of a double strand break. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 809, 70-80.
  • Choi EH, Yoon S, Kim KP. (2018). Combined Ectopic Expression of Homologous Recombination Factors Promotes Embryonic Stem Cell Differentiation. Molecular Therapy. 4, 1154-1165.
  • Kim C, Yang J, Jeong SH, Kim H, Park GH, Shin HB, Ro MJ, Kim KY, Park YJ, Kim KP, Kwack KB. (2018). Yeast-based assays for characterization of the functional effects of single nucleotide polymorphisms in human DNA repair genes.PLoS ONE 13, e0193823.
2017
  • Choi EH, Yoon S, Park KS, Kim KP. (2017). The Homologous Recombination Machinery Orchestrates Post-replication DNA Repair During Self-renewal of Mouse Embryonic Stem Cells.Scientific Reports. 4, 1156-1165.
  • Lee MS, Joo JH, Kim KP. (2017). Roles of budding yeast Hrr25 in recombination and sporulation. Journal of Microbiology and Biotechnology. 27, 1198-1203.
  • Kong YJ, Joo JH, Kim KP, Hong S. (2017). Hed1 Promotes Meiotic Crossover Formation in Saccharomyces cerevisiae.Journal of Microbiology and Biotechnology. 27(2): 405~411 
  • Choi EH, Yoon S, Hahn Y, Kim KP. (2017). Cellular Dynamics of Rad51 and Rad54 in Response to Postreplicative Stress and DNA Damage in HeLa Cells. Molecules and Cells. 40, 143-150.
  • Yeom JH, Joo M, Lee B, Kim KP, Ha NC, Park Y, Bae J, Lee K. (2017). Intracellular delivery of recombinant proteins via gold nanoparticle-DNA aptamer composites is independent of the protein physicochemical properties and cell type.Journal of Industrial and Engineering Chemistry. 45, 5-10.
2016
  • Yoon SW, Lee MS, Xaver M, Zhang L, Hong SG, Kong YJ, Cho HR, Kleckner N, Kim KP. (2016). Meiotic prophase roles of Rec8 in crossover recombination and chromosome structure. Nucleic Acids Research. 44, 9296-9314.
  • Kong SY, Kim KS, Kim J, Kim MK, Lee KH, Lee JY, Oh N, Park JI, Park JH, Heo SH, Shim SH, Lee DR, Kim KP, Park KS. (2016). The ELK3-GATA3 axis orchestrates invasion and metastasis of breast cancer cells in vitro and in vivo. Oncotarget 40, 65137-65146.
  • Park JH, Kim KP, Ko JJ, Park JS. (2016). PI3K/Akt/mTOR activation by suppression of ELK3 mediates chemosensitivity of MDA-MB-231 cells to doxorubicin by inhibiting Autophagy. Biochemical and Biophysical Research Communications. 477, 277-282.
  • Cho HR, Kong YJ, Hong SG, Kim KP. (2016). Hop2 and Sae3 Are Required for Dmc1-Mediated Double-Strand Break Repair via Homolog Bias during Meiosis. Molecules and Cells. 39, 550-556.
  • Challa K, Lee MS, Shinohara M, Kim KP, Shinohara A. (2016). Rad61/Wpl1 (Wapl), a cohesin regulator, controls chromosome compaction during meiosis. Nucleic Acids Research. 44, 3190-3203.
  • Jin SH, Jang SC, Lee B, Jeong HH, Jeong SG, Lee SS, Kim KP, Lee CS. (2016). Monitoring of chromosome dynamics of single yeast cells in a microfluidic platform with aperture cell traps. Lab on a Chip. 16, 1358–1365.
2015
  • Hong S, Choi EH, Kim KP. (2015). Ycs4 is required for efficient double-strand break formation and homologous recombination during meiosis. Journal of Microbiology and Biotechnology. 25, 1026-1035.
  • Lee MS, Yoon SW, Kim KP. (2015). Mitotic cohesin subunit Mcd1 regulates the progression of meiotic recombination in budding yeast. Journal of Microbiology and Biotechnology. 25, 598-605.
  • Lee MS, Yu M, Kim KY, Park GH, Kwack K, Kim KP. (2015). Functional Validation of Rare Human Genetic Variants Involved in Homologous Recombination Using Saccharomyces cerevisiae. PLoS ONE 4, e0124152.
  • Park SM, Kim KP, Joe MK, Lee MO, Koo HJ, Hong CB. (2015). Tobacco class I cytosolic small heat shock proteins are under transcriptional and translational regulations in expression and heterocomplex prevails under the high-temperature stress condition in vitro. Plant, Cell & Environment. 38, 767-776.
  • Koo HJ, Park SM, Kim KP, Suh MC, Lee MO, Lee SK, Xinli X, Hong CB. (2015). Small Heat Shock Proteins Can Release Light Dependence of Tobacco Seed during Germination. Plant Physiology. 167, 1030-1038.
2014
  • Yoon SW, Kim DK, Kim KP, Park KS. (2014). Rad51 Regulates Cell Cycle Progression by Preserving G2/M Transition in Mouse Embryonic Stem Cells. Stem Cells and Development. 23, 2700-2711.
  • Zhang L, Wang S, Yin S, Hong S, Kim KP, Kleckner N. (2014). Topoisomerase II Mediates Meiotic Crossover Interference. Nature 511, 551-556.
2013
  • Hong S, Kim KP. (2013). Shu1 Promotes Homolog Bias of Meiotic Recombination in Saccharomyces cerevisiae. Molecules and Cells. 36, 446-454.
  • Hong S, Sung Y, Yu M, Lee MS, Kleckner N, Kim KP. (2013). The Logic and Mechanism of Homologous Recombination Partner Choice. Molecular Cell. 51, 440-453.
2011
  • Kim KP, Yu JH, Park SM, Koo HJ, Hong CB. (2011) . Tobacco mitochondrial small heat shock protein NtHSP24.6 adopts a dimeric configuration and has a broad range of substrates. BMB Rep. 44, 816-820.
  • Zhang L, Kim KP, Kleckner N, Storlazzi A. (2011). Meiotic double-strand breaks occur once per pair of (sister) chromatids and, via Mec1/ATR and Tel1/ATM, once per quartet of chromatids. Proceedings of the National Academy of Sciences of the United States of America (PNAS).108, 20036-20041.
  • Park A, Jeong H, Lee J, Kim KP, Lee C. (2011). Effect of shear stress on the formation of bacterial biofilm in a microfluidic channel. BioChip Journal . 5, 236-241.
2010
  • Keun P. Kim, Beth M. Weiner, Liangran Zhang, Amy Jordan, Job Dekker, and Nancy Kleckner. (2010). Sister Cohesion and Structural Axis Components Mediate Homolog Bias of Meiotic Recombination. Cell 143, 924–937.
  • Keun Pil Kim, Yun-Gon Kim, Chang-Hyung Choi, Hye-Eun Kim, Sang-Ho Lee, Woo-Suk Chang and Chang-Soo Lee. (2010). In situ monitoring of antibiotic susceptibility of bacterial biofilms in a microfluidic device. Lab Chip, 2010, 10, 3296–3299.
2009
  • C. Danilowicza, C. H. Lee, K. Kim, K. Hatch, V. W. Coljee, N. Kleckner and M. Prentiss. (2009). Single molecule detection of direct, homologous, DNA/DNA pairing. Proceedings of the National Academy of Sciences of the United States of America(PNAS) 106,19824-19829.
2008
  • R. Koszul, K.P. Kim, M. Prentiss, N. Kleckner, and S. Kameoka. (2008). Meiotic Chromosomes Move by Linkage to Dynamic Actin Cables with Transduction of Force through the Nuclear Envelope. Cell 133, 1188–1201.
  • Jennifer J. Wanat, Keun P. Kim, Romain Koszul, Sarah Zanders, Beth Weiner, Nancy Kleckner, Eric Alani. (2008). Csm4, in Collaboration with Ndj1, Mediates Telomere- Led Chromosome Dynamics and Recombination during Yeast Meiosis. PLoS Genet 4(9): e1000188.
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